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TNF-alpha and IL-1beta modulate blood-brain barrier permeability and decrease amyloid-beta peptide efflux in a human blood-brain barrier model

For example, researchers focus on: Investigating metabolic signaling pathways

High mobility group box 1 (HMGB1) serves as a key nuclear protein, representing a damage-associated molecular symbol when exists in extracellular environment

Introduction The development of new compounds in recent decades has substantially improved the pharmacotherapy of type 2 diabetes (T2D) by improving achievement of metabolic targets while mitigating specific side effects (e.g., weight gain, hypoglycemia) frequently observed in patients treated with traditional hypoglycemic drugs such as insulin and sulfonylureas